Endocrine Abstracts

Background and objective: The upcoming new marketing presentations GLP1 analogues with a dosage more comfortable for patients, we wanted to revise the two we currently have on the market. The target of this study is to determinate glicated hemoglobin (HbA1c) at 6 months of treatment, changes in weight, body mass index (BMI) and tolerance.Design and methods: Observational study that included 60 patients with diabetes mellitus type 2 followed in two Intern...

Background and objective: Combination therapy in diabetic patients is seeking better clinical outcomes by acting on different targets in the pathophysiology of the disease.Insulin glargine provides excellent glycemic control, especially in the fasting glucose control, in spite of a increasing in weight, compared with exenatide which is more effective in controlling postprandial glycemic and in reducing insulin resistance, plus a reducing effect on the we...

There is a direct relation between the degree of glycemic control and the incidence and progression of diabetic complications. In addition improving glycemic control improves diabetic complications.Aim: To assess the degree of glycemic control, according to published guidelines, in treated type 2 diabetes mellitus patients who live in a district of Madrid, Spain.Methods: Cross-sectional study in 501 consecutive patients with T2DM w...

KNDy neurons, which co-express kisspeptins, neurokinin B (NKB) and dynorphin (Dyn), play a key role in the tonic control of gonadotropin secretion by modulating the GnRH release. The assumed KNDy model proposes that NKB and Dyn (as stimulatory and inhibitory signals, respectively) auto-regulate the secretion of kisspeptins onto GnRH neurons. However, some aspects of this paradigm remain poorly defined. In this context, the aims of this work were to characterize i) the putative...

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

Transforming growth factor β (TGFβ) signals through activation of Smad transcription factors, which bind to Smad binding elements (SBEs) in target genes. TGFβ can promote cancer cell proliferation and invasion, and plays a key role in the pathogenesis of scleroderma and other fibrotic disorders. We have previously shown that the thyroid hormone receptors (TRs) can block tumor growth and invasion. We now have analyzed the possibility that TRs could antagonize TGF...

Background: Previous studies have suggested that serum thyroglobulin (Tg) levels at the time of 131I remnant ablation just after thyroidectomy, could be a prognostic tumor marker in differentiated thyroid cancer (DTC).Objective: The aim of this study was to evaluate if serum preablation Tg in the earliest postoperative period could be useful for predicting persistence or recurrence of disease.Methods: This study was a retrospective...

Introduction: Thyroid ultrasound is a widely used tool in monitoring thyroid nodule, allowing us to assess the size and other sonographic signs suspicious of malignancy, facilitating decisions about diagnosis and treatment.Objectives: To evaluate the presence of ultrasonographic signs suggestive of malignancy in patients with thyroid carcinoma in our hospital.Material and methods: Retrospective study of 63 patients with thyroid car...

Introduction: Pregestational diabetes is a threatening condition for pregnancy; a strict glycemic control can decrease some pregnancy complications. That control can be achieved while on multiple daily insulin injections (MDI) treatment or with subcutaneous insulin infusion systems (CSII). Up to now no benefits of CSII treatment over MDI on pregnancy outcomes have been proved.Design: Case control retrospective study, comparing glycemic control and pregna...

Introduction: Protocols for identifing and managing hyperglycemia and diabetes in hospital are necessary. Glycemic goals in non critical inpatients are:140 mg/ml(preprandial) and 180(posprandial),oral antidiabetic drug(OADs) withdrawn, avoid hypoglycemias, basal/bolus insulin (nor sliding scale) and request glycosylated haemoglobin.Aims: To evaluate the implementation of a protocol for management of diabetes(PHD) during the years 2009 and 2010 in our Hos...